ADVANCED PHARMACOLOGY - I

Book excerpt: The fascinating world of “Advanced Pharmacology I" is the subject to explore. This book takes us on an exciting journey through the rapidly evolving science of pharmacology, where novel concepts and groundbreaking findings are transforming our understanding of and reliance on medicine. The subject is designed to strengthen the basic knowledge in the field of pharmacology and to impart recent advances in the drugs used for the treatment of various diseases. In addition, this subject helps the students to understand the concepts of Pharmacological and mechanisms involved. This book's rigorous planning ensures a thorough comprehension of the subject matter by covering a broad variety of subjects that line up with the drug actions. We go into the fundamentals of controlled medication delivery systems in Unit I. We discuss general pharmacology, in which we discuss drug development, drug distribution, drug safety, and effectiveness. Further, the new drug development and its stages have been considered. In the next chapter of Unit 1, the concepts of pharmacokinetics and pharmacodynamics are presented. In pharmacokinetics, we investigate the drug's absorption, distribution, biotransformation, and elimination. Concepts of linear and non-linear compartment models and in pharmacodynamics, the mechanism of drug action, receptors, structural and functional families of receptors, and quantitation of drug-receptor interaction have been briefly discussed briefly. Neurotransmission is introduced in Unit II. We explore the general concept of neurotransmission in this unit. Neurohumoral transmission in the autonomic and central nervous systems has been discussed here. Further, we discussed the concept of NANC. In Unit III, we address systemic pharmacology, in which we go through the pathophysiology of diseases, mechanisms of action, pharmacology, and toxicology of existing as well as novel drugs. It has been looked into how parasympathomimetics and sympathomimetics affect the neuromuscular junction and how they affect the autonomic nervous system.