This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim resul

Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientis

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design,